Thursday, May 29, 2025

Assault or Homicide!

Athabasca Glacer

I was asked at a dinner if Paracetamol was a safe pain killer to take. My friends were so shocked to hear that 8 tablets might be enough to kill: yes 8 of the 500mg ones!

Cordelia 

Cordelia did not fit into the usual overdose teenager profile. I felt it safer to admit her to our adolescent unit.

She was from an upper class family. Her mother was a Lady, but was in her second marriage. Cordelia was from a previous marriage although little was known of her father. Mother provided very little information about the father except that Cordelia never knew him. My charge nurse whispered to me that in fact mother told him Cordelia was born outside wedlock.

At first, I thought it might be difficult for Cordelia to fit in with our adolescent unit crowd. On the contrary, possibly because many of the anorectic girls came from middle class families, she settled in and befriended the girls in no time, mixing in extremely well, too well perhaps.

I later discovered that the girls loved her because she ‘helped’ them. Yes, she did, by cleaning their plates.

Her mother was still in Verbier with her husband on a skiing holiday. As Cordelia’s life was not medically in danger, mother decided to finish her week of skiing instead of rushing back. She overdosed on her mother’s homeopathic medication as soon as mother and stepfather left for their vacation. Luckily the maid discovered the empty bottles and got her admitted to the paediatric ward, before I transferred her over to the adolescent unit.

Many overdoses happened when parent or parents were away for whatever reason. The worst case I never had a chance to see or treat. A girl took a massive dose of paracetamol and left a note to her single mother, who was spending the night with her new boy-friend and never came home until the next afternoon. By the time this mother got her daughter into hospital, it was rather too late for the drip and the girl died a very painful death. I believe some responsible chemists have now put a limit on the amount they sell to teenagers.

Friday night I had a call from the same junior who was in trouble for prescribing too little benzodiazepine for the alcoholic.

Cordelia took a massive overdose of Paracetamol, and we found the empty packets. We could not check blood level because she is afraid of needles.”

“But she is not afraid of razor blades, from the look of the cuts on both her wrists!”

Having dealt with so many overdose and self-harm cases over the years, I probably sounded blatantly unsympathetic.

“How did she get so much Paracetamol anyway?”

“The Anorectics helped get them for her.”

She ate their food, and they got her what she needed to kill herself! Nice deal.

Is this what friendship is about? Helping Anorectics not to have to eat? Helping Cordelia to commit suicide? Getting even!

If she really swallowed down that many packets, her liver will be damaged soon. What should I, mmmm, we do? Her parents are not here to give parental consent. It is so late or in fact so early in the morning, that it would be tricky to get hold of them. Would we be contravening her human rights if we were to drip her against her will?”

“Where is she?”

“Acute Medical as the Paediatric Ward is not geared to deal with such a case. My friend is on call at Medical, so I asked for a favour and got her transferred there. Sorry!”

“Brilliant! There is nothing to be sorry about. We have a life to save here!”

“My friend at Medical said she will need to drip her soon or her liver would be damaged and she will die. She said she will drip her if you OK it and blood level will be checked at the same time.”

Smart girl. We need more junior doctors like her to save lives!

“They will make sure she won’t be able to rip the drip off. My friend said she needs the consultant to OK it and it is going to be you instead of their own consultant as she is primarily a psychiatric patient.”

I told her that ASSAULT is always a lesser crime than HOMICIDE, even culpable homicide and I would OK it if they accept my authorisation over the phone. I would come in to sign the notes as soon as possible. She passed the phone to her friend who sounded very efficient and professional.

We are still at an age when saving lives is our number one priority, human rights or whatever.

Cordelia was saved. Blood level result proved that we or the Acute Medical Team was right in wanting to drip her ASAP.

But this was a small hospital, word got round quickly.

Was I wrong to force treatment on a patient without parental consent?

What could I say? If I had not done what I did, the patient would have died. In any case, I was in loco parentis as she was not an adult and her parents could not be contacted. In the worst case scenario, I could have been charged with ASSAULT and that in fact would have been far less serious than death and a culpable homicide offence, as I explained to my Junior on the night of the incidence.

What about the deal between Cordelia and her anorectic friends? Both parties might be guilty of manslaughter!



Extracted from the following book:


The Cockroach Catcher II: Attempted Living


USA: Check it out on Amazon


Cockroach Catcher-Seven Minute Cure













The Cockroach Catcher II: Attempted Living---Daimler and The Vagabond

The Cockroach Catcher II: Attempted Living---He Did Not Show

The Cockroach Catcher II: Attempted Living---Life is a Beach

The Cockroach Catcher II: Attempted Living---Incestuous Failure

The Cockroach Catcher II: Attempted Living.




 

Monday, May 26, 2025

GBM: Glioblastoma Multiforme------Pork and Unusual Treatment.

 © Am Ang Zhang 2015   

                                                                                                      
A short while back I blogged about GBM and how an innovative treatment may have helped. Being a doctor Dr Anderson noted this:
My wife, Carmen Alicia, called a local friend, also a cardiologist, who sent us to a nearby hospital; there, an MRI exam revealed a small spot on my brain. The neurologist felt it needed to be biopsied to obtain a tissue diagnosis. I immediately returned to Virginia and went to several specialists, who suggested further testing before I decided to have an invasive brain biopsy. I also had a blood test for cysticercosis, an infection that results from eating undercooked pork contaminated with Tenia solium. This common parasite produces cysts all over the body, including the brain. It is the most common reason for seizures in many countries, particularly in India, where children with seizures are first treated for this disease even before other studies are done. My blood test was strongly positive. I started a course of oral medicine to treat it. The test reassured me.
My later research showed that there may indeed be some association of Tenia and GBM. 



Neurocysticercosis (NC) is the most frequent and widespread human parasitic infection of the central nervous system (CNS). Glioblastoma multiforme (GBM) is a neoplasm of CNS in elderly population and may have a similar clinical and radiologic presentation as of NC. The coexistence of NC and neoplastic intracranial lesion in an individual is a very rare entity. The incidence of NC among intracranial space occupying lesions is reported to be 1.2-2.5%.[1–4] Though cerebral cysticercosis may be associated with glioma,[5] but this rare coexistence of NC and brain tumors puts into question a causal relationship between the 2 diseases. Here we report a case in which glioma and cysticercosis appeared concomitantly, with continuing progression of low grade Glioma to high grade Glioma (GBM, WHO grade IV).


So some religious dogma might actually be good for ones health. 


But watch out, even if you do not eat pork:


Neurocysticercosis in an Orthodox Jewish Community in New York City



All the patients and their families adhered to Orthodox Jewish dietary laws, which forbid the eating of pork. Moreover, T. solium taeniasis due to the ingestion of contaminated pork is extremely unlikely in the United States. Cysticerci were detected in only 3 of more than 83 million hogs examined after slaughter under federal inspection in 1990.
The most likely sources of infection in the patients described in this report were women living and working in the patients' homes who had recently emigrated from Latin American countries where T. solium infection is endemic.

In 2003 the world was in the grip of a new plague that challenged our knowledge of medicine to its limit.

         For the first time, doctors and nurses who were normally in the forefront of the fight against diseases were fighting for survival from SARS (Severe Acute Respiratory Syndrome), a new and dangerously contagious disease.  The alarm was first raised by its first victim, Carlo Urbani.  He was an Italian physician employed by the World Health Organisation (WHO) and based in HanoiVietnam and he gave the disease its current name. It was as if this newly mutated virus knew what it was on about. Get the doctors as they would be the first who could deal with you. Urbani died. So did some of the medical staff that attended the first few patients.

         Doctors often thought that they would be immune, a God given right I suppose.  Not so this time! The virus obviously knew what it was doing.



A doctor friend had just been diagnosed with GBM (glioblastoma multiforme) grade IV. My hospital librarian had the same tumour and told me that the hospital neurosurgeon got it too. Another close friend who is an ENT surgeon has just been diagnosed with NPC (Nasopharyngeal Carcinoma).

Looks like doctors are no longer as immune as we like to believe and that goes for those that worked closely with doctors like our beloved librarian.                                                                .

More about the DOCTOR I mentioned earlier:

He is a cardiologist for thirty five years, (so not a neurosurgeon then) but with the diagnosis his research unravelled one of the possible reasons for "catching" GBM.
Why?

Why did this tumor happen to me? I never smoked and had had no brain injuries, and there is no history of such tumors in my family. As a cardiologist, I had implanted close to 400 pacemakers in my life and during the procedure was exposed to ionizing radiation (X-rays). In the early days we used portable X-ray machines and gave ourselves some protection by using thin lead gowns. Nowadays, heavy lead gowns are worn, and doctors and technicians protect their thyroid and eyes with shields and glasses. We also use heavy sheets of radiation-protective glass that hang from the ceiling.

At some point in my research, I was surprised by an article by a Johns Hopkins-trained cardiologist who now practices in Israel. He had collected data on 23 invasive radiologists and cardiologists who had developed tumors, of which 17 were GBMs on the left side of the brain. I wrote to the author, who told me that he had learned of several more such cases since his article was published, and he added mine to his file."

GBM

" I had a glioblastoma multiforme (commonly called a GBM) grade IV. This is the most malignant brain tumor; no grade II or III exist. A glioblastoma is what killed Sen. Edward M. Kennedy (D-Mass.) in 2009. While rare, it is the most common of the brain tumors. The prognosis is dismal; on average, patients survive only 14 months after diagnosis even with chemotherapy and radiation. After five years, only 5 percent of patients are still alive."

So depressing.

But wait: The Zapping!

" The Preston Robert Tisch Brain Cancer Center at Duke University has the largest experience on the East Coast with my sort of tumor, so I went there for further consultation and treatment.

As doctors there examined me, it was obvious that my tumor had already grown again; in fact, it had quadrupled in size since my initial chemo and radiation. I was offered several treatments and experimental protocols, one of which involved implanting a modified polio virus into my brain. (This had been very successful in treating GBMs in mice.) Duke researchers had been working on this for 10 years and had just received permission from the FDA to treat 10 patients, but for only one a month."

The procedure:

"I was given the Salk polio vaccine to prevent a systemic polio infection.


At Duke, my skull was opened under local anesthesia and I had the viral infusion dripped through a small catheter directly into the tumor in my brain for six hours."

The result:

"I returned to Duke a month after the infusion, and though an MRI showed some expected swelling, the more significant fact was that the tumor had stopped growing. I have gone back to Duke every two months since then, and the tumor, initially the size of a grape, is now a scar, the size of a small pea. It’s been two years since the initial biopsy and radiation, and one year since the experimental polio viral treatment, and I have no evidence of recurrence nor tumor regrowth.

According to a presentation about the research that the Duke doctors gave last May, the results so far are promising: “The first patient enrolled in our study (treated in May 2012) had her symptoms improve rapidly upon virus infusion (she is now symptom-free), had a response in MRI scans, is in excellent health, and continues in school 9 months after the return of her brain tumor was diagnosed. Four patients enrolled in our trial remain alive, and we have observed similarly encouraging responses in other patients. One patient died six months following ... infusion, due to tumor regrowth.” They added: “Remarkably, there have been no toxic side effects ... whatsoever, even at the highest possible dose.”

That has been true for me. I feel as fit as I was three years ago, before the first symptoms of the glioblastoma made their appearance. I remain only on an anti-seizure medication."


Laoshan China

 © Am Ang Zhang 2011    


Thirty years ago, I saw mountains as mountains, and waters as waters.

When I arrived at a more intimate knowledge, I came to the point
where I saw that mountains are not mountains, 
and waters are not waters. 

Thirty years on,
I see mountains once again as mountains, and waters once again as waters.
                                
 Adapted from Ching-yuan (1067-1120)