Showing posts with label brain. Show all posts
Showing posts with label brain. Show all posts

Wednesday, July 21, 2021

Music & Knowledge: Mozart & Brain!

© 2005 Am Ang Zhang
As the cock crowed, the grandfather left the house on his half mile walk to the little park by the river for his morning Tai Chi with a group of seniors. He was in fact the leader of the group and it fell upon him, a young looking 83 year old to go through the sequence of Tai Chi moves that had been passed down by his grandfather and others before him. His wife sometimes accompanied him but today she had to baby sit the grand-children as their parents were on an early shift. When they finished they sat around for some social chat and drank green tea from their thermal flasks. He walked home refreshed from the morning’s exercise and social gossips. As he neared home he could hear his grand-daughter practicing the piano. What lovely Mozart! He stepped into the house to find his grandson busy at a Nintendo game.

“Why aren’t you practicing your violin? If you just play computer games, your brain will turn into water.”

His grandson shut down the Nintendo, “Grandma, you should try it some time. It will be good for your brain.”
 “I am too old for it. My brain is all water anyway, according to grandpa!” She just remembered that she had to take her Ginkgo capsules.


The grandson played some scales on the violin and then the Vivaldi A minor. From memory, as that was how he was trained.

At breakfast, the young children listened to Grandpa reciting ancient classical Chinese poems - a long standing family tradition. Soon the grand-children left for school.
Grandma now cracked some walnuts while grandpa got ready to go to the market to see what fresh fish he could buy that day. The walnut was to go with their home reared free range chicken. They grew their own vegetables too.

Later that day they would be having a good game of Mahjong with a retired couple.

Much of what they did would help to maintain their brain fitness.

Ginkgo biloba with its romantic botanical history is no longer the Dementia buster it promised to be. (Those who know of the village in Japan where there are loads of Ginkgo trees could have told you that. The village has the highest Alzheimer rates in Japan.)

I was reminded of Woody Allen’s film, Radio Days, where the young Allen (who else) was brought before the Rabbi by his mother for his advice because Allen was hooked onto the radio. The Rabbi’s skepticism was perhaps not that dissimilar to ours nowadays about iPhones, computer games and brain exercises. Indeed the young Allen should be concentrating on his upcoming Bar Mitzvah and the Torah memorizing.

The Old views on Brain.

When I was training in London in the 70s, I spent some time at Queen Square. Those in the know will recognize it as the place for neurology this side of the Atlantic. It was drilled into us then that sadly we were given a number of brain cells when we were born and it was all downhill from then on or something to that effect. It was well known that neurologists were great diagnosticians but for most neurological conditions, not much could be done. How depressing indeed. Even as recently as four weeks ago, I heard a young doctor told his father that there was nothing he could do with his brain cells. One is given so many at birth and no more can be expected. Lord Brain (1895-1966) would have been so proud.

Yet it was also London that shook the world with new discoveries about the brain, and the study was on the most unlikely group of people: Taxi drivers. Their “KNOWLEDGE” was the basis of our knowledge on brain plasticity today. The “KNOWLEDGE” is a term officially used to describe the test the Taxi Drivers had to take to get the licence to drive Taxis in London. Streets in London have evolved over time and are not on any grid system at all. Early postmortem examinations led some pathologists to note the small size of the Taxi drivers’ frontal lobes. Yet actual weight measurement showed that size was all relative. It was the enlarged hippocampal region that created that impression. Later work using modern scanning techniques confirmed the early impressions.

If two to four years of “KNOWLEDGE” acquisition can change the size of the brain in a grown adult, what else could we do?

The rest, as they say, is history.



The book covers the changes to the brains of musicians and medical students. It tells us that just three months of memory work can have noticeable effect on the brain of medical students, and music memory work has similar impact on musicians. I was pleased to learn that Bilingualism helps too. From infancy, I and my siblings were brought up with speaking two Chinese dialects at home.

Will medical schools that have abandoned traditional teachings please bring back Anatomy-the old way?

Mozart & Music
Is the piano China’s answer to the problem that is facing many parents in the west, i.e. ADHD? Could it be a novel substitute for Ritalin and other stimulants? With the advent of unproven modern approaches to education at all levels, very few subjects require memory work. Yet in the last decade or so, memory work has been shown to be beneficial to “brain power”, leading to a whole new approach to neuroplasticity. Learning a musical instrument is one way to give the brain the right amount of training. 

Did the 300,000 or so that took up piano this year in China know a thing or two about brain plasticity? Currently 30 million children are reported to be learning the piano in China.

For now, just as the west is abandoning classical music training as part of the school curriculum, parents in China are paying for their children to have piano lessons. By some reckoning, North America probably consumes 90% of Ritalin and similar stimulants, whereas China is probably consuming 90% of the pianos produced. One factory in the south of China is currently producing 100,000 pianos a day.

As a child psychiatrist, I find the ones on ADHD showed great promise but I doubt if we are ever going to see the end of the stimulants’ hold on the condition in the West. It is interesting to note that Stimulants never took off in China, a country with a fifth of the world’s population. Computer games, on the other hand, have really taken off there.

Bridge and Sudoku were mentioned in passing, along with other favourites like crosswords. There is no mention of Mahjong although in the East it is all the rage, nor the memory work required in some religions. Their gods might know a thing or two about the brain.

Mozart's birthday: 27 January 1756


Saturday, July 19, 2008

The Open and The Brain

“If you have a 10 handicap you would have shot 130 today.”



Credit: John Biever/SI

That was the comment made today by one of the Golf Channel commentators at Royal Birkdale on the third day of the 137th Open Championship. The wind was brutal on this Links course. A real test not of strength and distance but of skill and course management.


Credit: John Biever/SI


Greg Norman, the 53 year old newly wed will be going into the final day as the leader, seeking golf’s most sought after title.


Credit: John Biever/SI

He is of course married to Chris Evert the tennis legend and if he should win tomorrow he would become the oldest man to have won a Major, not to say The Open. He has not even played that much golf recently. Yet on the first two days he single putted 17 holes including a 50 footer. Perhaps his brain has been well primed by years of putting, more years than any of the other players.

We shall know soon enough.

Golf Posts:

Golf and Disability
Golf, Cholera and Tiger Woods
Ancient Remedy: Modern Outlook
Golf and Health
Tiger Woods and Breathing
Autism, the Brain and Tiger Woods

Wednesday, July 2, 2008

Hot Brain

PLoS Biology
In today’s New York Times:
“The new report, published in the free-access online journal PLoS Biology, provides the most complete rough draft to date of the cortex’s electrical architecture, the cluster of interconnected nodes and hubs that help guide thinking and behavior. The paper also provides a striking demonstration of how new imaging techniques focused on the brain’s white matter — the connections between cells, rather than the neurons themselves — are filling in a dimension of human brain function that has been all but dark.”
PLoS Biology
This is literally a wiring diagram: a new tool for psychiatrists perhaps? This professor is really excited:
“This is just about the coolest paper I’ve seen in a long time, and forward-looking in terms of where the science is going,” said Dr. Marcus E. Raichle, a professor of neurology and radiology at Washington University in St. Louis.
The study was a collaboration that included the University of Lausanne in Switzerland, Harvard and Indiana University using a new technique called diffusion spectrum imaging.
PLoS Biology
For those interested read the full article in PLoS Biology and they should have the last words:

Future improvements in diffusion imaging and tractography, as well as computational network analysis, will no doubt reveal additional features of the connectional anatomy of the human brain. It will be important to include major subcortical regions, such as the thalamus, into future network analyses. Another advance would be to parcellate cortex not on the basis of sulcal and gyral landmarks, but rather on the basis of regularities in functional connections that are observed in individual participants [49,50].

Our data provide evidence for the existence of a structural core in human cerebral cortex. This complex of densely connected regions in posterior medial cortex is both spatially and topologically central within the brain. Its anatomical correspondence with regions of high metabolic activity and with some elements of the human default network suggests that the core may be an important structural basis for shaping large-scale brain dynamics. The availability of single-participant structural and functional connection maps now provides the opportunity to investigate interparticipant connectional variability and to relate it to differences in individual functional connectivity and behavior.

Thursday, May 22, 2008

Senator Kennedy, Gliomas and Vesicular Stomatitis Virus (VSV)

Some Bugs May Be Useful

In The Cockroach Catcher:

“……Nature is of course not about beauty or beauty alone. Beauty is both deceptive and subjective. To love only the beautiful and good and dislike the ugly and bad is missing the point ……
Wildlife is just wildlife. Not good. Not bad.”


As most now know, American Senator Edward Kennedy has been diagnosed with
glioma.

From the
New York Times:

“Mr. Kennedy’s glioma is in the parietal area in the upper part of the left side of his brain, above the ear. This area of the brain involves motor control and ability to understand language, among other functions.

Malignant brain tumors rarely spread elsewhere in the body. But like the root of a plant, cancerous brain tumors can invade nearby areas in the brain.

Gliomas are categorized by subtypes and by a numerical gradation based on how aggressive they appear. But the doctors did not provide these details or the tumor’s size, saying only that the diagnosis was made by removing a small piece of the cancer in a biopsy, which followed a series of other tests that began after Mr. Kennedy suffered a seizure on Saturday morning.”



A viral view: Researchers at Yale University have genetically engineered a virus (green) that specifically attacks brain tumors in mice (red). The virus kills the primary tumor masses (B) and migrating tumor cells (E), while leaving healthy tissue intact. Credit: Van den Pol/Yale University

I read about this in MIT’s Technology Review

Systemic Vesicular Stomatitis Virus Selectively Destroys Multifocal Glioma and Metastatic Carcinoma in Brain

The Journal of Neuroscience, February 20, 2008, 28(8):1882-1893

Here is a relevant extract from the MIT review:


“.....Now researchers at Yale University have found that a virus that's in the same family as rabies effectively kills an aggressive form of human brain cancer in mice. Using time-lapse laser imaging, the team watched
vesicular stomatitis virus (VSV) rapidly home in on brain tumors, selectively killing cancerous cells in its path, while leaving healthy tissue intact. What's more, Anthony Van den Pol, lead researcher and professor of neurosurgery and neurobiology at Yale, says that VSV is able to self-replicate and produce secondary lines of defense.
A metastasizing tumor is fairly mobile, and a surgeon's knife can't get out all of the cells," says Van den Pol. "A virus might be able to do that, because as a virus kills a tumor cell, it could also replicate, and you could end up with a therapy that's self-amplifying.
His search for a virus candidate began six years ago, when he and his colleagues tested the effect of different viruses on brain tumors in culture. Repeatedly, VSV came out "at the top of the heap." The team grew the virus through many generations, isolating strains that infected cancer cells quickly while having a slow effect on healthy cells. The researchers recently ran the most effective strain through a number of tests in live mice, and they've published their results in a recent issue of the Journal of Neuroscience.
In its experiment, the team transplanted glioblastoma--the most common and aggressive form of human brain cancer--into the brains of mice. Prior to transplantation, researchers genetically engineered the tumor cells to express a red marker, which, once inside the brain, would show up in laser microscopy scans. Similarly, Van den Pol inserted a green marker in VSV cells and injected the virus intravenously through the tail. Within a few days, researchers observed that the green virus found its way to the brain and selectively infiltrated red tumor masses and individual tumor cells, while avoiding normal cells. Van den Pol says that as the virus infects tumors, cancerous cells start to turn green, swelling up until they eventually burst.
…… It's not yet clear why VSV is such an effective tumor killer, although Van den Pol has several theories. One possible explanation may involve a tumor's weak vascular system. Vessels that supply blood to tumors tend to be leaky, allowing a virus traveling through the bloodstream to cross an otherwise impermeable barrier into the brain, directly into a tumor.
Van den Pol says that VSV may also target cancer cells because of inherent defects in a tumor's immune system. Typically, in the presence of a virus, normal cells launch an immune response by producing interferon, proteins that prevent viral infection in healthy cells. Tumors lack such strong viral defenses, providing an easy target for viruses.”


As this is still in the early experimental stage, it may not be an option for Senator Kennedy right now. Vesicular stomatitis virus (VSV) belongs to the Rhabdoviridae family, as does the well-known Rabies virus. It is worth remembering that in nature there is no bad or good, and biodiversity is going to prove important to our future health. There is every reason to preserve the most virulent bug on planet Earth and perhaps in the whole universe. Cockroaches, on the other hand, require no preservation. They just survive!


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Sunday, February 24, 2008

'The Knowledge' and the Brain

Early on in my neurological training at one of the world’s top centres, we were told in no uncertain terms that we were born with a fixed number of brain cells which would not be replenished whatever we might do.  At the time and for a long time afterwards I believed them.  So did most doctors and neurologists and the public in general.  Now I realise that in life what you and a lot of people have always believed in may turn out to be not true.


‘The Knowledge’ unique to London is what blew that belief into pieces. All London taxi-driver have to go through two to five years of training to learn and memorise all the London streets (about 25,000 in total within a six-mile radius of Charing Cross) and one-way systems.   In the licence examination they have to answer questions on how to drive from A to B along the shortest possible route.  The scientists in London did MRI studies of these London taxi-drivers and confirmed that the specific part of their brains that is responsible for this visual-spatial memory had indeed become bigger and more complex than average. What we previously knew about the brain had to be deleted and a new chapter was re-written.   Brain injured people began to have new hope.
In my travels I have come across minority ethnic groups that give their children very specific motor skill training in the form of traditional dances and games, and on the small island of Taquile in Peru, even knitting for boys – perhaps they know a thing or two.

Island of Tequile, Peru

Peruvian boys in Tequile

One can argue that computer games are the modern equivalent.
Playing musical instruments requires both manual dexterity and memory work, and musicians are often good mathematicians, possibly because of the proximity of the areas in the brain for these functions, although it may not be that clear cut. Making children recite poems is not a bad idea either, nor indeed the study of Latin, as these activities all help to exercise their brain. 


The Jewish have probably known for a long time the benefit of studying the Torah for Bar Mitzvah:
“……It is most common for the celebrant to learn the entire haftarah portion, including its traditional chant, and recite that.”

Now lessons in music instruments are no longer offered in most state schools in the U.K., nor is Latin. Medical schools are moving away from rote learning. Good intentions may indeed have major drawbacks that could affect generations to come.

By the way, if you have been trained to have a good memory, that ability will transfer easily to the remembering of the taste of wine! Think about it, the brain is very economical in its application, and is still the best computer around.

Mmmm….perhaps that is why two of my friends started learning the piano when they retired. They too might know a thing or two.

If we want our children to have a future, bring back music, rote learning and poetry, and let medical students toil through anatomy. Our world will be better.