Saturday, August 30, 2008

A Brief History of Time: CPR (Cardiopulmonary Resuscitation)

In April, my good friend the cardiologist in California received an email from one of his friends on the subject of “New AHA rules for CPR finally released to the general public”.

It read:

Thanks to you, I'd had a two year head start on this subject that's only this week published in the popular press. When you first advised me on it, I'd forwarded that info to all my friends. Believe it or not, a GI friend of mine actually saved a life at a wedding last year. Some elderly gent at his table suddenly collapsed to the floor without a pulse. He remembered the article I'd forwarded him and began vigorous CPR without giving mouth to mouth. That gent survived to thank him. Indirectly, of course, he's thanking you.”

My good friend has been interested in the subject of CPR for many years and provided me with some interesting material on the history of CPR, which I share with you below.

History in the Western World

1891: The first external cardiac massage in the Western world was reported to be done successfully by Friedrich Maass.

1960: Kowenhoven and Knickerbocker reported their method in JAMA that chest compression was accepted as a method of resuscitation for cardiac arrest.

1966: The first guideline for CPR was published.

1970: Teaching the lay public to do CPR was started.

1974: American Heart Association (AHA) formally promoted the practice involving the combination of rescue breathing and external cardiac massage for cardiac arrest in a ratio of 2:15.

2005: Ewy in Arizona showed that hands-only CPR, at a rate of 100 per minute until the emergency crew armed with automated cardiac defibrillators arrive, was superior to the traditional method of CPR.

My friend immediately drew the attention of his colleagues in Hong Kong to Ewy's work and suggested that the lay public should be taught this simplified method of CPR to encourage bystanders to give aid to victims of cardiac arrest. Many bystanders would otherwise be reluctant to help for fear of contracting AIDS through traditional mouth-to-mouth resuscitation to these strangers.

The AHA was hesitant to accept Ewy's idea in their new guidelines for CPR in 2005, but as a compromise, recommended a ratio of 2 breaths to 30 chest compressions instead.

2007: In March The Lancet reported a Japanese study on a series of over 4000 cases in Tokyo, comparing traditional CPR to hands-only CPR by bystanders. The results showed that the latter was more successful in the resuscitation of cardiac arrest with preservation of neurological function.

2008: In April, the AHA finally gave its approval on hands-only CPR from bystanders. The link has a video demo.

To date I could not find any hands-only CPR in NICE and the St John’s Ambulance site is still in the 2/30 era.

Luckily for the wedding guest, his friend did not wait for the AHA recommendation nor any British ones.

History in Traditional Chinese Medicine

403-221 BC: (Warring Kingdoms period) External cardiac massage was practised as a method of resuscitation for victims of suicide by hanging. Some credited this to Bian Que.

6 BC - 221 AD: (Eastern Han Dynasty) The first description of CPR for resuscitation of victims of hanging came from Zhang Zhongjing.

In his Essence of the Golden Chest, miscellaneous therapy #23, he described the method as follows: "Lower the victim gently, don't just cut the rope, and lie him on the blankets. One person should put his feet against the shoulders of the victim and pull on his hair, rendering it taut (to open the airway). One person should put his hands on the victim's chest and compress rhythmically (external cardiac massage). One person should flex and extend the victim's limbs (to promote venous return). One person should press on the victim's abdomen (to enhance intrathoracic pressure during external cardiac massage). ....This method is the best and usually successful."

Zhang Zhongjing's writings were handed down and read by Chinese physicians through the centuries.

1186-1249 AD: (Sung Dynasty) The above passage in Essence of the Golden Chest was cited by Sung Ci in his book on forensic medicine “Washing Away of Wrongs (Xi Yuan Ji Lu)”, which is recognized as the first book of forensic medicine in the world and has been translated into many languages both in Asia and Europe.

There is much we can learn from the past. One may even save a life.

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Thursday, August 28, 2008

Golf Tour’s New Rule: Speak English to Stay in Play

The New York Times headline:

Golf Tour’s Rule: Speak English to Stay in Play

“Concerned about its appeal to sponsors, the women’s professional golf tour, which in recent years has been dominated by foreign-born players, has warned its members that they must become conversant in English by 2009 or face suspension.”

With 43 of the top 100 players in the LPGA from Korea, Taiwan, Japan and other countries in Asia, the LPGA must have employed some great lateral thinker.

If you cannot beat them in golf, make sure you can with a new rule.

The Cockroach Catcher checked the latest version of Rules of Golf from the Royal and Ancient and the USGA. Not there.

LPGA is different, my golfing partners told me this morning.

The trouble is that most of these young girls move to Florida anyway and in less than six months they can speak better English than any American player can speak Korean, Japanese or Mandarin.

Canada's Lorie Kane
does not think LPGA's English rule is the answer:

"Right now we have an awful lot of tournaments internationally and a lot of them are in Asia. I don't speak any Asian languages. If we continue to play over there, are they going to require me to speak Korean?"

Luckily they did not have such rules in Psychiatry otherwise I would not have had the pleasure of listening to Anna Freud and a number of others with their heavy Viennese accent.

I can see that there will be a number of English language coaches prospering in Florida. What if you speak Scottish? Even I find that hard to understand sometimes.

What about
Padraig Harrington?

Harrington is not playing in the LPGA.

Golf Posts:

Golf and Disability
Golf, Cholera and Tiger Woods
Ancient Remedy: Modern Outlook
Golf and Health
Tiger Woods and Breathing
Autism, the Brain and Tiger Woods

Wednesday, August 27, 2008

Psychiatry and Religion

The following is extracted from The Cockroach Catcher: Chapter 29 The Power of Prayers.

According to old Chinese advice, it is wise never to discuss politics or religion even amongst best friends.  Religious belief can often blur judgement in the wisest of people. In psychiatry it is sometimes not easy. This is particularly true in cases of florid psychosis, which often presents with symptoms of hallucination, delusion and even vision.
         I remember my early days of psychiatry in a mental hospital in Hong Kong. Yes, it was the days of 2000-bed hospitals. Yes, it was the days of Medical Superintendents who had supreme power and all doctors of whatever rank and experience were Mental Health Officers with special authority to sign papers for compulsory admissions. The forensic unit was contained within the same complex.
         Those were the days when we encountered psychosis in the raw so to speak. All the colony’s really mad people were admitted to this one place set in the furthest corner of the colony. In our year seven of us decided without much discussion that we all wanted to go into psychiatry. That was over 10% and all had quite idealistic reasons. It was perhaps a bit of a disappointment to our parents that we did not pursue a more conventional specialty that might provide us with more status and financial reward. Then there was the fear of contamination that somehow one might become mad too. Recent day medical students are said to shy away from psychiatry for these same reasons.
         Education seems to have little effect on superstition.
         I can vividly remember the day when three coach loads of a particular church descended at the front entrance to our hospital. We had one of those grand gates which somehow were never locked. Those that needed to be locked up would have been detained in their individual hospital wards. The hospital had extensive grounds, and was the only non-high rise public hospital in Hong Kong. Wards were individual self-contained buildings spread like a horseshoe, and in all there were eighteen of them. The wards were given numbers without names but the numbers served the same purpose: 3 was for acute male, 11 for GPI[1]’s and so on and so forth.
         Only the maximum security wards were air-conditioned to satisfy prison standards.
         In the middle of the horseshoe was the main medical block – the Medical Superintendent’s suite and the different staff rooms. Then there was the administration block where the kitchens were located. Laundry, refuse disposal etc. were a bit away from the main buildings, so was the Mortuary. Yes, there was a Mort. On call doctors carried out post mortems and very rarely would any outside pathologist be called in. There was much trust in doctors then. As there were dementia wards, people did die of natural causes especially when the weather changed.
         In a matter of a few weeks we learned a good deal. We learned a good deal about acute psychosis. We also learned a good deal about the other end of the spectrum, that of chronicity and dementia. We also became aware that suddenly we were no longer lowly medical students. Even though we were still junior we had certain status. Now someone cleaned our car every day for a small fee. The guards at the gate saluted you. The local restaurants knew there was a new group of doctors who would lunch regularly. Even the local shopkeepers gave us special treatment.
         Imagine the shock when three coach loads of church people descended upon this Institution to challenge one of its doctors.  The patient in question was a girl, and amongst other psychotic symptoms she had a vision. She was admitted the night before as she became unmanageable at home. She was sectioned and was now in the care of the team to which one of my good friends belonged. As luck would have it he was a devout Christian and managed to defuse the situation. Yes, she could be having a vision. Yes all necessary investigation would be carried out including that of the nervous system as she might have a brain tumour. Yes, please continue to pray for her. Yes, it could be the work of the devil.
         There was no brain tumour.
         There was no religious vision.
         The prayers worked.  She had a good doctor – my friend.  She was put on Stelazine[2].

         Some time in early February of 1978 I was called to do a Home Visit on a thirteen year old girl by Dr Pinkerton, a paediatric consultant. Dr Pinkerton had been the local Paed for years and was generally well regarded. She had, in my short time as consultant, referred a couple of cases, most notably that of a Tourette[3] syndrome and a boy with non-stoppable hiccups. Both cases put me in her A-list and I gathered that not many were on that list. Needless to say I realised too that her cases were never straightforward or simple.  Those she would have dealt with herself. The girl had upper arm stiffness on the left side and Dr Pinkerton could not find much else wrong with her, and so it crossed her mind that perhaps there was something psychiatrically wrong.  The girl was also carrying out some strange rituals around the house and Dr Pinkerton did wonder about psychosis or even catatonia[4].
         One of my two clinics was in this so called “new town”. Basically it was an idea conceived after the war in about 1949. The idea was that if people were moved out of the inner city their life would improve.  Because they often moved the same people from the same area to the exact same street in the new town the problems travelled with them. Old foes stayed in the same streets as warring neighbours. Yet generations of Local Councils continued to move people into newer housing estates, not understanding why they never managed to solve the problem.  I had visited a few of these new towns.
         The family I had to visit luckily did not have any enemies but they only moved three months ago and felt very isolated. They moved from a very tough neighbourhood in London not to get away from difficult neighbours. They moved because their daughter did not fit in. She was a timid shy adolescent who did not do normal South London teenage things and was becoming ostracised. She was not into drugs, smoking or drinking or even sex.  To her peers she was a weirdo.  After the move, father was able to find a job at the local airport and mother worked part time as a dinner lady at the local school. Feeling isolated, they went with a neighbour to a local church group and both parents had recently been converted.
         I was asked very early on by mother, although father did try to stop her, if this might be the work of the devil. She heard that the devil was always trying to do nasty things to anyone who had just become a Christian although she also heard that it could sometimes be God himself wanting to test her faith.
         Memories about my friend and the vision girl flooded back and I had not even had a chance to see what the problem was.
         I saw what mum meant. The girl was ignoring my presence. She was mumbling to herself and pacing around the room with a semi-fixed gaze. She held her left arm stiff in a half-raised position and was going round the room as if looking for bits of dirt on the wall and rubbing it.  It started about two days before when the parents came home from a church prayer meeting to find her non responsive. Since then she had had sips of water but hardly ate anything. Dr Pinkerton came out straight away to see her and called me in.
         There was really no significant medical or psychiatric history in the family. She was an only child with the history of the usual childhood ailments. She was average at school though the year before she was not performing well because of problems with other girls. Both parents were healthy although I noticed that mum was nursing a cold sore.
         I did wonder if catatonia was making a come back but the golden rule in psychiatry, as in General Medicine, is: if in doubt, observe.
         I told mother that it might be better if we got her into hospital for observation. After all they probably needed a break as they did not have any sleep properly since this started. The parents did try to take turns to catch some sleep but as father still had to go into work it was very exhausting.
         “But it would not be the mental hospital.”
         “No, it would be one of my beds in the paediatric ward, although it would not be the same hospital as Dr Pinkerton’s.”
         “Anything would do, Doctor. We leave it in your hands.”
         Even when we did not know what was going on, we had learned how to keep that from our patients. Was it cheating or was it just good doctoring? Patient’s confidence in you is as important as your medical knowledge. Perhaps that is why doctors are not doing so well nowadays.
         “You will sort her out, won’t you, doctor?”
         “Sure we shall. In hospital we can run a few tests including those on the brain just in case and then we can proceed with treatment.”
         “Have you seen cases like this before?”
         “Sure, not that many but we sure have.”
         What else could I have said? To be honest, I am only a junior consultant and I have never seen anything like this before, any further question?
         “I know you are good.  You have helped the boy with the swearing at our church. He now hardly swears.”
         My goodness. It is a small place.  I have been here only three months and people already know.
         All I knew was it would be easy enough if it was indeed the start of a psychotic illness and all would be all right though sad.
         I must first exclude rare but serious neurological conditions.
         I had no idea what was to hit me in the next twenty four hours.
         The hospital to which she was admitted was built during the war by Canadian soldiers. It was unusual for an English Hospital as all the wards were built of Red Cedar. All the wards were linked by covered walkways. Over time we all became very fond of it - a true cottage hospital. Everybody was friendly. Consultations were easy to arrange in such a place; I had used my two bed allocation regularly and had developed a good working relationship with the paediatric nursing staff. In fact the Tourette boy was one of the first admitted for observation and proved to be a great hit. Most had never heard of such cases and the few that had had never seen one. Then I had the boy who refused to eat what most others liked and I soon became the psychiatrist that brought interesting cases.
         They could not wait for my next case. Maybe not.
         Sister Clark used to be at University College Hospital in London where I had the good fortune of gaining some paediatric training. She moved here to look after her eighty eight year old mother. We knew we were in safe hands as there was nothing to replace a good Sister on any ward. They reminded us of important things to look out for and basically if we were not too pompous they would look after us. That way we tended not to miss a thing clinically.
         When I reached the ward after my day’s clinic, Sister took me to the nursing station. She said the girl was either pregnant or she had a full bladder. A quick examination revealed a soft mass up her umbilical level.
         How stupid of me. Remember: every female of child bearing age is pregnant until proved otherwise. Mother’s reassurance that she was not like the other girls fooled me. She must have found it difficult to tell her parents and therefore was in such a difficult psychiatric state. Faking mental illness would be one good way out.
         I thought: great!  At least I could deliver. Pregnancy test and OB consult and that would be it.
         But hang on. Would mother not notice her sickness if she was this big? Would she not have complained about other symptoms? Something was not fitting in. And she still looked pre-pubescent.
         Perhaps we should catheterise her. She had not been seen to use the toilet for hours although she was not drinking much. She was still going round in her room – we gave her the side room and a nurse – and we put on an input output chart so we knew. The new junior doctor’s car broke down so she was late in examining her.
         Bother, I forgot it was changeover time, when new doctors came in for their new six-month rotation.  This is one of the days of the year not to be ill.
         “Good work Sister. What do we do without you?”
         Sister did the catheterisation but only got about 150ml. The mass was still there.
         I phoned Ob-Gyn. The consultant had left for home, but I got her Senior Registrar.
         He came over. Yes, it was possible that she was pregnant but unlikely as there were no breast changes. He would hate to do an X-ray but that seemed justified in the case of an undiagnosed abdominal mass.
         My mind was racing now. Sometimes you do have to believe what you see. Sometimes you have to believe the parents. She was not one of those girls. She could not be pregnant. So now we had to go through the differential diagnosis for abdominal mass in a young girl of thirteen.
         Ovarian cyst was the obvious one.
         This big?
         No. It cannot be.
         The x-ray came back. The tell tale tooth was there and yes – a Teratoma[5], the distinctive type of tumour that can include teeth, hair, sometimes, even a jaw and tongue.  I guessed just a split second before the results came back. How annoying.
         Working diagnosis: Teratoma with possible toxic psychosis.
         Emergency operation was arranged. Yes, she would be fine a little while after the operation, I reassured the parents.
         The paediatric junior arrived and took some history and did a quick physical before she was prepared for the theatre. This petite doctor with a very babyish face told me that on her first day in her last job she had to do an emergency tracheotomy. This time she had been on call for the last three nights and the battery in her old Mini could not cope with the heavy frost so she had to wait for AA before coming. She was most apologetic for not having got in earlier.
         She asked if I had seen many toxic psychosis cases and I asked if she had come across any in her psychiatric placement. As with all good psychiatrists answering a question with another is in our blood and here it worked well.
         Neither of us knew what was to hit us next.
         At 2 A.M. I had a call from her.
         “Your patient – I mean our patient could not be aroused after the operation. Yes they removed the teratoma, complete and intact. It is bigger than any specimen I have seen but she could not be aroused.  Any ideas?”
         “Call the paediatrician on call in the regional paediatric unit and I will be in.”
         What happened?  I asked myself as I drove to the hospital.
         What had we done? This was fast becoming a nightmare situation.
         What was I going to say to the parents?
         Something else was going on here, and I was not happy because I did not know what it was. I was supposed to know and I generally did. After all I was the consultant now.
         Thank goodness she could breathe without assistance. That was the first thing I noticed. I saw mother in the corner obviously in tears. She asked if her daughter would be all right. I cannot remember what I said but knowing myself I could not have said anything too discouraging. But then I knew I was in tricky territory and it was unlikely to be the territory of a child psychiatrist.
         A good doctor is one who is not afraid to ask for help but he must also know where to ask.
         “Get me Great Ormond Street.”
         “I already did.”
         She is going to be a good doctor.
         “Well, the Regional unit said that they had no beds so I thought I should ring up my classmate at GOS and she talked to her SR who said “send her in”.”
         Who needs consultants when juniors have that kind of network?  This girl will do well.
         “Everything has been set up. The ambulance will be here in about half an hour and if it is all right I would like to go with her.”
         “Yes, you do and thanks a lot.”
         I told mother that we were transferring her daughter to the best children’s hospital in England if not in the world and the doctor would stay with her in the ambulance. She would be fine.
         When I got into work later that day, my secretary asked how my patient was as she heard from her friend that the church was going to hold a 24-hour vigil for her.
         Trust my secretary. She knew someone from the same church and she always had the knack of extracting information first hand.
         “They say this may be the work of the devil as the doctors and surgeons all did the right things and removed this big tumour but the devil must have got to her.”
         I did have a vague fear that there might have been some anaesthetic accident but quickly told myself off for thinking along that line. I knew all the anaesthetists and such a thing could never have happened.
         I was back at the hospital to deal with an overdose case. The junior was there and we had a chat in Sister’s office.
         They had to ventilate her. That was the first thing she told me. I thanked her for going up there and she said it was scary but she felt important and the mother who was in the ambulance could not thank her enough.
         She was impressed with mother’s faith and trust in God.
         She said mother was near to tears. It was bad enough to have such a large Teratoma and then to have the patient unconscious with no one knowing what was going on was very frightening.
         “I have seen some deaths as a medical student but never since I was registered. I do not want this to be my first.”
         I knew the feeling well but what could I say? A doctor has to face it some time.
         “Do you believe there is God?” She asked
         “Do you really think I can answer that one?”
         “Well, you have more experience.”
         “To me it is like reading a good book. You would not know until the end.”
         “So you mean I am not going to know until then.”
         “Interpret whichever way you like. I remember Jung in his Memoir gave quite an account on the Holy Trinity.  There were seventeen bishops in Jung’s family including his own father. Jung had always been puzzled by deity and the bible and most of all by the concept of the Holy Trinity. I know many religious philosophers struggle with that too. By some accident he had access to his father’s inner library. He saw this folder clearly marked Holy Trinity. The relief was phenomenal. He could now have the answer. He hesitated before opening the folder.”
         “What did the folder contain?”
         “See, you want the last chapter. I wanted to know as well. The folder contained pieces of blank paper.”
         “That was it?”
         “That was it.”
         “Well. My view is this. We are here. We live. We help others to live and maybe we do not ask too many questions and we might or might not in the end know the answer.”
         “But do you think this girl is going to live though? I do not want this girl to be my first death. It would be so awful.”
         “Neither do I. I keep saying to myself that it is now over seventy two hours and she is still alive and I do know that some cases of viral encephalitis can be very dramatic in presentation and recovery.”
         “But which virus?”
         “The nearest I have is Herpes.”
         “Mother’s cold sore.”
         “You have noticed that too.”
         “I was with her for a long time.”
         We had our own prayer for her too. Let it be Herpes encephalitis and all would be well.
         I left the hospital feeling slightly strange. I just had a philosophical encounter with a young doctor. How strange it is that threats of death always get one thinking about these things.
         The girl remained unconscious although the word was that the EEG was more hopeful than was first thought.  GOS decided to transfer her next door to Queen Square - National Hospital for Nervous Diseases. A lumber puncture[6] was done and the initial findings were in keeping with viral encephalitis. They were now trying to grow the virus. They also wanted Queen Square to decide on assisted ventilation.
         There was now a candlelight vigil at the church and it was hoped that there would always be a lit candle until she came home. The story was in the local paper and radio. Faith was now on field test if not on trial. The doctors were not. They had done their best.
         On the 10th day the ventilator came off, and she was able to breathe without support.
         They then started a vigil in the girl’s home.
         By the 23rd day, as my optimism was about to give in, word came from the hospital that she became conscious. It became big news in the papers.
         When mother came home from London, she came to see my secretary to give her the details. She told my secretary that she always knew that her daughter would live.
         No virus was ever isolated and her diagnosis on discharge was that she had a variant of Encephalitis Lethargica[7].
         “Did you agree with the diagnosis?” The junior asked me when I saw her next.
         “Why should I be arguing with the best neurological centre in the world? It is harder to argue with a variant of Lethargica. However the next few months or years will be important. If she is well then Herpes fits in better and often it is an allergic type of reaction on first exposure. But if she is like those in Awakenings[8], then Encephalitis Lethargica.”
         I saw her at the local hospital rehab a couple of times. Initially there were a good deal of residual symptoms including awkward gait and dis-inhibition. She became better and was moved to a specialised centre and that was the last I heard of her.
         Ten years later mother came to see my secretary and left a photo. It was a photo of her daughter and her new baby. She had been working at the local bank since she left school, met a very nice man and now she had a baby. Mother thought I might remember them and perhaps I would be pleased with the outcome.
         I was very pleased for them too but I would hate for anyone to put faith or god to such a test too often.

[1] GPI - General paresis of the insane.  A now-rare neuropsychiatric disorder affecting the brain and central nervous system. A late complication of syphilis.

[2] Stelazine - trifluoperazine hydrochloride, an antipsychotic widely used for schizophrenia before the new generation of drugs came on the market.

[3] Tourette syndrome - Over 100 years ago, the French physician Georges Gilles de la Tourette wrote an article in which he described nine individuals who, since childhood, had suffered from involuntary movements and sounds and compulsive rituals or behaviours. In his honor, this constellation of symptoms was named Gilles de la Tourette's Syndrome. Today, we recognize that Tourette's is a spectrum disorder, with some people having a few tics and others having tics plus features of other conditions such as obsessions, compulsions, inattention, impulsivity, mood variability. Once thought to be a rare condition, Tourette's is a fairly common childhood-onset condition.

[4] Catatonia - Catatonia is a disturbance of motor behaviour that can have either a psychological or neurological cause. Its most well-known form involves a rigid, immobile position that is held by a person for a considerable length of time— often days, weeks, or longer. It can also refer to agitated, purposeless motor activity that is not stimulated by something in the environment. A less extreme form of catatonia involves very slow motor activity. Often, the physical posture of a catatonic individual is unusual and/or inappropriate, and the individual may hold a posture if placed in it by someone else.

[5] Teratoma – Teratomas are tumors comprising more than a single cell type derived from more than one germ layer. Usually, dermoid cysts contain representative tissues of the three embryonic germ cell layers: ectoderm, mesoderm and endoderm. Sebaceous material, hairs, cartilages, teeth, even thyroid tissue are frequently observed. A well-formed jaw and tongue has been reported. Teratomas of other organs have also been reported to contain teeth.

[6] lumbar puncture – A lumbar puncture (also called a spinal tap) is a procedure to collect and look at the fluid (cerebrospinal fluid, or CSF) surrounding the brain and spinal cord. 

[7] Encephalitis Lethargica - a disease characterized by high fever, headache, double vision, delayed physical and mental response, and lethargy. In acute cases, patients may enter coma.
[8] Awakenings –  Oliver Sacks’ remarkable account of a group of patients who contracted sleeping-sickness during the great epidemic just after World War I. Frozen in a decades-long sleep, these men and women were given up as hopeless until 1969, when Dr. Sacks gave them the then-new drug L-DOPA, which had an astonishing, explosive, "awakening" effect. This account inspired the 1990 film of the same name, starring Robert De Niro and Robin Williams.

Post Script:
“Ten years later mother came to see my secretary and left a photo. It was a photo of her daughter and her new baby. She had been working at the local bank since she left school, met a very nice man and now she had a baby. Mother thought I might remember them and perhaps I would be pleased with the outcome.
I was very pleased for them too but I would hate for anyone to put faith or god to such a test too often.”

Tuesday, August 26, 2008

Grand Rounds (4) 48, 49

Rural Doctoring Grand Rounds (4) 49

Shakespeare's Seven Ages of Man was the theme of this week's best medical blogs from around the world!

The blog is on Small-town Medicine in the Internet age and the Rural Doctor can really write. A lot of thought was indeed put into fitting in the best Medical Blogs around the globe.

Here is the quote from her Grand Round:

"The lean and slippered pantaloon should watch out for slubs in the carpet, because as he ages he's at more risk of slipping and breaking a bone, and the resulting MRSA osteomyelitis might just kill him. Read the Cockroach Catcher's take on the scenario."

Six Until Me: Grand Rounds (4) 48

A really good Diabetes Site. This week she uses a traditional library catalogue to present the best of Medical Blogs around the globe.
Mine is listed under 600: Technology and Applied Science.

"The Cockroach Catcher gives us a post about lithium to treat bipolar disorder, and how only time will tell if this is the best method."

Grand Rounds


Sunday, August 24, 2008

Anorexia Nervosa: Bach

In under an hour, Chinese cellist Jian Wang takes the stage of the Royal Albert Hall for the first three of Bach's six solo suites, works of towering technical accomplishment as well as intellectual and spiritual nourishment.
  • Suite No.1 in G major for solo cello
  • Suite No.2 in D minor for solo cello
  • Suite No.3 in C major for solo cello
“Jiang Wang comments that 'Bach's music has a lot of qualities that appeal to the Chinese philosophy of life: to be humble, to wish but not desire, to love but not own. This is all in Chinese philosophy, and because I grew up with those values, these things are dear to me. When I listen to Bach's music, it confirms all of that.'” From the BBC website.
In The Cockroach Catcher Dr Zhang got his Anorectic patient to play the cello that was banned by the “weight gain contract”:
“She missed the cello too, the only thing she could use to shut out her worries.
Fourteen and carrying the burden of the world.
She played a couple of scales and we made some fine tuning. It was not quite the same as the violin, but at least I knew not to overdo the pegs. Then she started playing.
“Ah. The Bach G-major”
“So you know it”
Of course I do. The hours I spent listening to Yo Yo Ma and it was such amazing music, melancholic and uplifting at the same time. For a moment I forgot that I was her psychiatrist and she forgot she was my patient.
“My grandma gave me Casals.”
I knew Casals was even more emotional than Ma, but Ma is Chinese and he was less affecting, allowing the listener to tune in to his own mood.
She played from memory. What talent! What went wrong?”

Saturday, August 23, 2008

Hospital Infection: Quorum Sensing

This is the story of a much respected retired professor. As he celebrated his 82nd birthday, we have to be thankful that he must have some strong genes to have survived the last eight months. An unfortunate slip at home fractured one of his ankles, and as a pin was needed a surgical procedure was performed in a local hospital by the Orthopaedic surgeon. For the following eight months an otherwise independent and healthy eighty one year old had to suffer the indignity of many more hospital procedures because of a lingering infection.
“I don’t know” was his answer when we visited him and asked if it was the dreaded MRSA.
He was never tested!
Nearly 15 years since the discovery of Quorum Sensing by Nottingham University the topic seemed to be shrouded in some mystery. The Cockroach Catcher read about it by chance in an airline magazine and his own survey of some recent medical school graduates from Cambridge and Southampton indicated that this was not in their curriculum and they had never heard of it.
There is of course a Nottingham Quorum Sensing website and certainly Cambridge produced some research papers.
Bonnie Bassler said that all we knew about bacteriology in the last 300 years is all wrong. Strong words indeed. So are we still teaching medical students all the wrong stuff?
Is professional jealousy at work here? Surely not. But Quorum Sensing will itself lead to other exciting findings about the world of the microbe that has so far got the upper hand on the ever so clever Homo sapiens.
Think MRSA and C.difficile and I am sure you will agree.
I know that it is a new field and much of it theoretical and conjectural but I was a medical student once and the greatest buzz for me then was Heart Transplant, and VAMP treatment for some kind of leukaemia. So could we not let the future doctors have some excitement other than the 3G iPhone?
Surely we need to inspire some great brains to go where no men have gone before.
It is now well established that in France and Holland where hospitals do not run to capacity, they do not have the level of MRSA and C. difficile problem that we have here.
I do not think that is the result of them using some of the methods we have been known to use here, i.e. not testing the patients. Their standard of care is probably different and their wards are not as crowded.
We do seem to have lots of “good” lateral thinkers working in the NHS. In the meantime, our well loved professor has decided to move to sheltered housing. Months of struggling with his immobility and inability to go walking, swimming, shopping and getting on with his daily chores robbed him of his desire to be independent. But at least he survived.
What about his hospital manager? Did he or she get the bonus?
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Monday, August 18, 2008

To Ban Or Not To Ban: BPA

In an earlier POST I noted:
“Bottled water had an average 160 ppt of antimony when opened immediately after bottling. But ground water stored in a PET plastic bottle had 630 ppt of antimony when opened six months later.”

Globe and Mail

In April the Canadian Government moved to ban BPA (Bisphenol A) in all baby bottles. A first step by any government to do so and now the first State in the US to do this might well be California as the LA Times reported:
"Californian lawmakers weigh ban on chemical found in baby bottles, although danger is in dispute."
Now the BPA coating is also used in canned food for sometime and there were concerns it might be implicated in
prostate cancer especially for babies exposed to BPA (a long lead time, you might think). Perhaps having baby food with lids lined with BPA is not such a clever idea after all.
“Wal-Mart Stores Inc. and Toys ‘R’ Us Inc. say they will stop selling baby bottles made with the chemical next year, and the maker of the hard-plastic Nalgene water bottles announced in April that it would stop using the chemical."

At least 11 other states have considered bills to restrict it.

“California's bill was approved earlier this year by the state Senate and it is awaiting a vote by the Assembly. It's not yet clear whether Gov. Arnold Schwarzenegger will sign it if the Legislature sends it to him.”

In the latest twist the Associated Press reported:
“FDA scientists said the trace amounts of bisphenol A that leach out of food containers are not a threat to infants or adults."
It is interesting that the evidence is supplied by the industry:
"'It's ironic FDA would choose to ignore dozens of studies funded by NIH(the National Institutes of Health) — this country's best scientists — and instead rely on flawed studies from industry,' said Pete Myers, chief scientist for Environmental Health Sciences." AP continued.
I wonder if FDA's Acting Commissioner Andrew von Eschenbach will be following Daniel Troy, (a former chief counsel at the FDA, as Glaxo’s new general counsel as reported by the the WSJ) and move to American Chemistry Council?
Or will the Terminator ban BPA anyway? Lets wait and see.