Nuremberg & Thalidomide: The Good The Bad & The Ugly.

It is not really the first time we visited a place that has a rather haunting history. St. Petersburg is one such place especially when one re-visited the whole sordid saga of the murder of the small children of the Russian Tsar family.

Now we are starting our high school reunion on our river cruise. The journey starts at Nuremberg. All of us of course remember the Judgment at Nuremberg. I decided to watch it again. The principle that just because your boss told you to do things in a certain way did not absolve you from the greater humanitarian aspect of what you do. This is most important for doctors and if you think we have shied away from the Nuremberg era, think again. In one way or another, those that dare speak out against what management in our beloved NHS does were met with some of the worst fates unimaginable in any democratic society.

Nuremberg of course was the famous setting for one of Wagner’s well known Operas, Die Meistersinger von Nürnberg which was in 2011 performed at Glydnebourne for the first time ever to much international acclaim. 

But Nuremberg was sadly linked to one of the worst drugs disaster of our time. This was uncovered by none other than Newsweek.

As they opened a new Waitrose across from my clinic, I find myself shopping there most days after work. It was one of those de-roling activity that is important after a whole day being involved in the mad of sad world of child psychiatry. John Barnes in Swiss Cottage was the first local store that was very close to the Tavistock Clinic where I trained. It was there that I saw the wooden escalator that my father reminisce about of the ones in Shanghai in the 40s. John Lewis and Waitrose remained my favourite haunt for all these years.

One day, at one of the specially designed check outs, sat a girl on a special raised mechanical chair was a girl with arms a quarter the size of ours and a few minute fingers. Yes, a Thalidomide victim doing a proper check out job.

Yes, we tried our best not to notice and our best not to treat her any differently as we well know that that is what she would want. I raised my hat to Waitrose for treating her like any of their partners. That is how the world should be.

But I never knew that there was any link between Thalidomide and Nuremberg. O.K. I knew Thalidomide was developed by a German Company, Grünenthal.

Nuremberg©2015 Am Ang Zhang

The Nazis and Thalidomide: The Worst Drug Scandal of All Time

Newsweek

Adding to the dark shadow over the company, it is increasingly clear that, in the immediate postwar years, a rogues’ gallery of wanted and convicted Nazis, mass murderers who had practiced their science in notorious death camps, ended up working at Grünenthal, some of them directly involved in the development of thalidomide.

 What they had to offer was knowledge and skills developed in experiments that no civilized society would ever condone. It was in this company of men, indifferent to suffering and believers in a wretched philosophy that life is cheap, that thalidomide was developed and produced.

Perhaps the best known of Grünenthal’s murderous employees was Otto Ambros. He had been one of the four inventors of the nerve gas sarin. Clearly a brilliant chemist, described as charismatic, even charming, he was Hitler’s adviser on chemical warfare and had direct access to the führer—and committed crimes on a grand scale. As a senior figure in IG Farben, the giant cartel of chemical and pharmaceutical companies involved in numerous war crimes, he set up a forced labor camp at Dyhernfurth to produce nerve gases before creating the monolithic Auschwitz-Monowitz chemical factory to make synthetic rubber and oil.

In 1948 Ambros was found guilty at Nuremberg of mass murder and enslavement and sentenced to eight years in prison. But four years later, he was set free to aid the Cold War research effort, which he did, working for J. Peter Grace, Dow Chemical, and theU.S. Army Chemical Corps. Ambros was the chairman of Grünenthal’s advisory committee at the time of the development of thalidomide and was on the board of the company when Contergan was being sold. Having covered up so much of his own past, he could bring his skills to bear in attempts to cover up the trail that led from the production of thalidomide back through its hasty trials to any origins it may have had in the death camps.

Dr. Kelsey, FDA scientist who kept thalidomide off U.S. market, dies at 101.

Dr. Kelsey is honored by President John F. Kennedy in 1962. (Courtesy of FDA)

The tragedy was largely averted in the United States, with much credit due to Frances Oldham Kelsey, a medical officer at the Food and Drug Administration in Washington, who raised concerns about thalidomide before its effects were conclusively known. For a critical 19-month period, she fastidiously blocked its approval while drug company officials maligned her as a bureaucratic nitpicker.

Freedom of Speech: Truth & Thalidomide!

Case 5 – The Truth about Thalidomide Given the lack of a constitution enshrining free speech, we do need some protection against frivolous libel actions and injunctions which try to prevent the truth from being revealed. Otherwise the truth about thalidomide would never have been told.

“Thirty-eight years ago,” he wrote, “I sat through days of hearings by the Law Lords deliberating on whether I and the paper I edited were guilty of contempt in 1972-3 in campaigning for justice for the thalidomide families. All five Law Lords voted to ban publication of our report. Only a 13-11 victory in the European Court of Human Rights removed the gag order” – and thus, I add, enabled The Sunday Times to expose one of the great scandals of that time, and subsequently win compensation for the families with young children born damaged or deformed, often without legs or arms, because their mothers had taken the drug, thalidomide, which was marketed as a mild sedative that would relieve morning sickness in pregnancy.                                                                                             Telegraph

Luckily, the European Court eventually ruled for The Sunday Times:

“The newspaper then decided to fight the injunction on its investigation into the origins and testing of the drug. The case went right through the British legal system and up to the European Court of Human Rights, which decided that the injunction violated the right of ‘freedom of expression’. The full story of thalidomide could eventually be told in 1976, revealing that both Grünenthal (the maker) and Distillers had not met the basic testing requirements of the time.”

I mentioned thalidomide also because in 2002 Gordon Brown, the then chancellor, attempted to tax the benefits payable through the Thalidomide Trust.

Thalidomide: how men who blighted lives of thousands evaded justice | Harold Evans | The Guardian

Guardian: UK

"The original catastrophe maimed 20,000 babies and killed 80,000: war apart, it remains the greatest manmade global disaster."

Up to 80% that took it were affected.

Sad read as you go on:

Grünenthal had insisted that it was blameless: the thousands of abnormal births were an act of God. 

Photo from the Guardian.

https://www.theguardian.com/society/2014/nov/14/-sp-thalidomide-pill-how-evaded-justice

The Cockroach Catcher II: Attempted Living

Touched Untouchable:

Charles was another case on my ‘untouchable’ list. He was arrogantly untouchable.

“You are the DOCTOR, you tell me what’s wrong with me!”

Not the best way to establish a therapeutic alliance, really. Arrogance I could deal with, and he found his match! Stubborn patients require stubborn doctors and arrogant patients? Not that different!

Contrary to what Charles thought, his opening line could not have been better. I replied:

“You’ll have to find that yourself!”

No harm was done. He kept his subsequent appointments without fail, telling me how he could not stand the Maths teacher nor the one teaching history, and I listened. Unfortunately he was one of the few cases about which I had no clue whatsoever.

“This young man could not sleep. Probably depressed. Please see.”

This was from our well known referrer who amused our social workers no end. At meetings, they always joked about his exceptionally short referral letters. This one was probably four words longer than his average. I had no problem with referrers who did not try to influence me.

Charles was sixteen years old, an only child from a fairly stable home. Father worked at the airport as a baggage handler and mother worked at a local school as a dinner lady for a few hours a day.

For some time now, Charles could not sleep at night and he would get so tired during the day that he dozed off during class. A locum GP thought he might be depressed and mentioned that in his notes. When Charles saw his own GP again, his GP referred him.

Apart from his difficulties falling asleep, I simply could not decipher him.

After a slow start, when Charles realised that I was not going to medicate or in his view, poison him, he started to talk.

He wanted to be a pilot. Not a baggage handler.

It was not too difficult to work out why.

His grandfather on mother’s side was a pilot in the RAF. He was unfortunately killed during the War.

Now he wanted to be a pilot but only for commercial flights.

We chatted and chatted and I still had no clue to the cause of his insomnia.

“You are the mind doctor! You should know!”

Then one day, my secretary buzzed me.

“Mum left something for Charles to take home. She said it was for him anyway and she had too much other shopping. Could he take them home?”

“Do you know what it is?”

“Yes, six huge bottles of Coke!”

Ah, Caffeine.

That was why my secretary called me! What did I tell you? I had good secretaries.

In medicine, sometimes the answer could be very simple. I wished I had worked it out before then.

Arrogant doctors need good secretaries.

“At school, I was told that we must drink at least three litres a day and I find it difficult to drink just water. So I went on to the sodas, whatever is on sale.”

Now that we had the answer, I must do my bit of doctoring.

“Try flavouring your water with a wedge of lemon or lime and see what happens.”

He was willing to give it a go.

“If it works, I am not psychiatrically ill then, and I don’t need to see you anymore. Correct?”

“Correct!”

He came back a week later.

“Now I can sleep like I used to. So I am fine! But I do want some advice on how I can earn some good money to get myself one of those expensive remote control planes?”

Wow, he wanted some advice! And toy planes!

I was tempted to say, “I thought you wanted to be a real pilot.”

But I resisted!

“Try the new Waitrose over there, they just opened.”

“Thank you, doctor. By the way, I like the lemon flavoured water.”

When I finished the clinic, I went over to the new Waitrose to see what I could get for dinner.

Who should be at one of the checkouts but my ‘arrogant untouchable’!

“That was quick!”

“Yeah, all the jobs were taken when I came over, but one of the new boys could not cope with the supervisor and left. I don’t mind. I think the other boy could not cope with her strange short arms and her being on a special electrical wheelchair. She was very nice to me and soon I forgot how she looked.”

Good for you untouchable. At last someone touched you.

Thank you, Waitrose¹, for having a Thalidomide victim in a supervisory position. I have trusted you to be my first store when I came to England and you will always be my favourite.

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For those who do not know, Waitrose is a brand of British supermarkets and part of the employee-owned retailer John Lewis Partnership.

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Cockroach Catcher-Seven Minute Cure